Postmarketing instances of respiratory despair, including fatalities, have been noted with utilization of promethazine hydrochloride in pediatric individuals under two yrs of age. A wide range of fat-primarily based doses of promethazine hydrochloride have resulted in respiratory depression in these people.

This product may perhaps include inactive components, that may result in allergic reactions or other challenges. Talk with your pharmacist For additional aspects.

Check your neighborhood drug store and clinics for consider-back locations. You can also Test the DEA Internet site for areas. Here's the link on the FDA Safe and sound disposal of medicines Web page: Precautions

Narcotic analgesics may lead to nausea and vomiting by stimulating the chemoreceptor cause zone (CTZ); even so, they also depress the vomiting Centre, to ensure subsequent doses are unlikely to make vomiting. Nausea is small right after standard oral doses of codeine.

Head Injury And Elevated Intracranial Pressure: The respiratory-depressant effects of narcotic analgesics as well as their capacity to elevate cerebrospinal fluid strain may be markedly exaggerated from the existence of head injuries, intracranial lesions or possibly a preexisting increase in intracranial pressure.

Together with its needed results, a drugs may well result in some unwanted consequences. Even though not these Unwanted effects may occur, should they do occur They could need health care awareness.

Should you be prescribed this medication on a regular agenda and miss a dose, acquire it the moment you bear in mind. Whether it is near the time of the next dose, skip the skipped dose. Choose your future dose for the standard time. Tend not to double the dose to catch up.

Promethazine and codeine must be made use of all through pregnancy provided that the opportunity advantage justifies the likely danger to the fetus.

Postmarketing conditions of respiratory depression, which includes fatalities, havebeen reported with usage of promethazine hydrochloride in pediatric patientsless than two a long time of age. A variety of body weight-dependent doses ofpromethazine hydrochloride have resulted in respiratory melancholy inthese individuals.

Codeine: Dosage of codeine SHOULD NOT BE Improved if cough fails to reply; an unresponsive cough should be reevaluated in 5 times or quicker for feasible fundamental pathology, including foreign human body or decreased respiratory tract disease.

Codeine: A research in rats and rabbits documented no teratogenic outcome of codeine administered in the period of organogenesis in doses starting from five to 120 mg/kg. From the rat, doses at the 120mg/ kg level, inside the toxic variety with the adult animal, have been affiliated with an increase in embryo resorption at some time of implantation.

The mix of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric sufferers lower than 6 a long time of age. Concomitant administration of promethazine merchandise with other respiratory depressants has an Affiliation with respiratory melancholy, and often death, in pediatric sufferers. The association does indirectly relate to individualized fat-primarily based dosing, which might otherwise allow Safe and sound administration.

Prior to using this medication, convey to your medical professional or pharmacist If you're allergic to any of its components; or to opioid suffering relievers (for example morphine); or if you have every other allergies.

Codeine is amongst the The natural way occurring phenanthrene alkaloids of opium derived from your Promethazine codeine syrup opium poppy; it is assessed pharmacologically being a narcotic analgesic.